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Gemcitabine (Gem) has been shown to be a more potent drug than cisplatin (Pt) in the treatment of human tumors. We evaluated its effect on human leukemia cell lines, and observed that a short-term Gem exposure, which produced little killing in the corresponding cancer cells, did not enhance long-term survival of Pt-resistant cell clones of either U937 or HL-60. The resistance of the clones to the combination of Gem plus Pt was attributed to a decrease in the accumulation of Pt, and we investigated the mechanism of this decline. There was a 3- to 4-fold increase in the intracellular Pt concentration in the U937 clones exposed to Gem for up to 48 h; there was a smaller, but still significant increase in the HL-60 clones. The decrease in Pt accumulation was not due to a decrease in the amount of the transmembr
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Buy one drink, get one free
You don’t need to hang around long if you’re after a bargain, buy one drink, get one free is a great idea. Treat yourself, buy a £6 Old Speckled Hen across the road and you’ll be given a free £6 drink if you’re there within an hour (or round the time your £6 drink runs out).
This Friday only is Birmingham Beer Week (as you may have noticed) so enjoy this chance to get a discount. Oh and if you’re feeling super rushed and still want to save a few quid why not try hitting up Speckled Hen – they’ll even give you a free pint when you’re finished!Profile of clinical features and cytological examinations of odontogenic cysts and tumours: a study of 929 cases.
An 8-year retrospective review of 929 odontogenic cysts and tumours was undertaken to demonstrate the diagnostic accuracy of Fine-Needle Aspiration Cytology (FNAC). The various odontogenic cysts and tumours were divided into those of odontogenic origin, those of non-odontogenic origin and those of mixed origin. The accuracy of the test was the percentage of correct diagnoses (characterised by sensitivity and specificity). The lesions of the various categories were as follows: odontogenic cysts 82.1 per cent (711); odontogenic tumours 73.1 per cent (618); non-odontogenic cysts (including inflammatory, reactive and benign tumours) 43.5 per cent (381); and non-odontogenic tumours 29.6 per cent (252). There was a very high incidence of FNAC in the diagnosis of odontogenic tumours (72.5 per cent), compared to that of non-odontogenic cysts (26.5 per cent) and non-odontogenic tumours (37.9 per cent) (P A separator of this type serves for separating gaseous components from a mixture of air/gas and which is sometimes referred to as blow-through compressor and which serves for cooling, and, in particular, for cooling the lube oil of the internal-combustion engine. G